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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At Lilly’s Biotechnology Center in San Diego, we discover medicines that address significant unmet needs by integrating biology with innovative scientific capabilities in RNA and computational sciences. We collaborate with colleagues in both the discovery and development organizations, including scientists in therapeutic area biology, biomolecule formulation and developability, ADME, Toxicology, PK/PD, Statistics, Computational Sciences, clinical development, and more.

We are seeking an experienced scientific leader to help drive our functional genomics initiatives and advance our oligonucleotide therapeutic pipeline. This role requires a strategic thinker who can bridge high-throughput genomic technologies with therapeutic development, leading cross-functional matrixed work to translate genomic insights into molecular understanding and help inform drug development decisions.

Key Responsibilities:

+ Lead and expand functional genomics efforts across the RNA therapeutics team to support oligonucleotide drug discovery and development programs

+ Design and oversee multi-omic approaches (RNA-seq, pro-seq, Ribo-seq) to characterize therapeutic targets and validate oligonucleotide mechanisms of action

+ Develop and implement in vitro pharmacology strategies for oligonucleotide screening and optimization. Experience with scaling NGS methods such as TAC-seq and 3’-end sequencing a plus.

+ Capable of leveraging public data repositories such as ENCODE, GEO, GTEx with in house data to help design and inform experiments.

+ Capable of mentoring and leading in a matrixed environment of genomic scientists, bioinformaticians, and molecular biologists

+ Collaborate with chemistry, DMPK, and toxicology teams to advance lead candidates through preclinical development

+ Establish computational pipelines for large-scale genomic data analysis and integration

+ Interface with external partners and present scientific findings to senior leadership and stakeholders

Basic Qualifications:

+ PhD in Molecular Biology, Biochemistry, Genomics, or related scientific field with 10+ years industry or academia work experience

Additional Skills/Preferences:

+ Deep knowledge of NGS technologies and their application to target validation and drug development

+ Demonstrated expertise in oligonucleotide therapeutics (ASOs, siRNAs, or related modalities)

+ Proven track record leading functional genomics efforts in drug discovery settings

+ Experience leading and working in matrixed cross-functional teams across complex research programs

+ Strong computational skills (Python, R, or similar) for genomic data analysis

+ Experience with automation, single-cell genomics, or spatial transcriptomics

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$184,500 - $321,200

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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