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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Position Summary:

The Diabetes, Obesity and Complications Therapeutic Area (DOCTA) of Eli Lilly and Company focuses on new therapeutic approaches for the treatment of diabetes, obesity and cardiometabolic diseases. Starting from an idea, we work with partners across Lilly to discover and develop novel biologic, small molecule and nucleic acid-based therapeutics. Our focus is the patient: by understanding the biology and pathophysiology underlying disease states, we aim to address the root cause of disease, and develop breakthrough therapies. We have one of the strongest pipelines in the industry and a track record of delivering impactful medicines that improve people’s lives.

We are seeking a visionary Human Genomics and Translational Data Sciences Lead within the DOCTA organization to drive our human genetics, proteomics, and exploratory clinical research into the future. This role requires a forward-thinking, passionate, and collaborative leader with a deep understanding and significant track record of applying internal and external data sets for disease target identification, indication expansion, subpopulation classification, and disease mechanism understanding. You will find new ways to address scientific questions using Lilly’s large in-house datasets and deep disease state expertise, and we expect you to push the boundaries of scientific innovation.

The Human Genomics and Translational Data Sciences Lead will lead a diverse team of in-house statistical geneticists and data scientists. You will represent the Data Science and Computational Biology (DSCB) group and DOCTA both internally and externally, including partnering with key opinion leaders and identifying strategic alliance opportunities in the human genetics and metabolism space. This is a unique opportunity to help build and advance a life-changing portfolio of medicines across research and clinical groups within DOCTA and Eli Lilly in one of the most exciting and dynamic fields of research today.

Key Responsibilities:

+ Provide scientific leadership and strategic vision in human genetics, proteomics, population data science, and clinical informatics to position Lilly at the forefront of genetics for diabetes, obesity, and complications

+ Lead and mentor a team with diverse computational background

+ Develop and implement strategies to optimally use public large-scale genetic/genomic resources (population-scale biobanks, genome sequencing initiatives) and integrate with patient-derived data from clinical trials to provide novel insights for Lilly’s portfolio

+ Lead efforts to analyze whole genome sequencing and proteomics data from clinical trial participants

+ Align with DOCTA’s strategic priorities and drive data-driven innovative approaches to identify and validate novel therapeutic targets

+ Spearhead cross-functional initiatives to translate genetic/genomic findings into actionable insights that inform drug discovery, biomarker development, and clinical trial design

+ Represent Lilly at scientific conferences and engage with the broader genetics/genomics community to stay at the forefront of innovation

+ Partner with internal teams to evaluate external innovation opportunities and bring insights to aid decision making

+ Interpret and clearly communicate results from genetic analyses, including development of scientific manuscripts, posters, and presentations; communicate the group’s vision and progress to internal and external partners

+ Implement industry-standard procedures for scientific project execution and documentation (e.g., JIRA, Confluence, Git, code review, and other documentation tools)

+ Accountable for the team’s development and documentation of reproducible pipelines for genetics analyses

+ Perform hands-on execution of human genetic analyses as needed

+ Foster a culture of scientific excellence, collaboration, and continuous learning within the human genetics and bioinformatics group and across the organization

Key Requirements:

+ PhD or equivalent in Human Genetics, Epidemiology, Clinical Informatics, or related field with at least 5 years in a leadership role; MD + PhD preferred

+ Demonstrated success in building, mentoring, and managing scientific teams (3+ years managing direct reports required)

Additional Skills and Preferences:

+ Led or played a significant role in high-impact research programs in pharma, biotech, or academia; knowledge of drug development strongly preferred

+ Prior experience with multiple in human genetics workflows including analysis of WGS, WES, and genotyping data for association analyses, polygenic risks score analysis, and analysis of rare variants, required

+ Prior experience working with clinical and observational biomedical informatics data sets, including data from clinical trials, EHRs, and large biobanks (e.g., UKBB), required

+ Prior experience with clinical/diagnostic genetics, including application of ACMG criteria for annotation of variant pathogenicity, strongly preferred

+ Strong track record of publications in top-tier journals

+ Strong collaborative approach with outstanding communication and interpersonal skills to engage cross-functional teams and external partners

+ Ability to prioritize and manage multiple competing priorities within a fast-paced environment

+ Demonstrated ability to lead and manage successfully within a matrixed organization

+ Strongly team-oriented with a customer focused design thinking mentality

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$184,500 - $321,200

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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