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Senior Research Associate, Disease Mechanism Research

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com .

Purpose and Scope:

The Disease Mechanism Research team at Astellas West Coast Innovation Center is looking for a passionate and driven individual to join our fast past paced team. This position will support oncology disease mechanism research with a dynamic drug discovery environment. The scientist will apply deep expertise in molecular biology, cell biology and histology to advance experimental strategies and data generation. This role will contribute towards efforts of understanding drug and disease mechanisms of action and will require collaboration with internal and external project teams to drive progress towards research milestones. This position will be located on site in South San Francisco.

Essential Job Responsibilities:

+ Design and perform in vitro studies to evaluate mechanisms of action of therapeutic molecules.

+ Perform a wide range of molecular biology (nucleic acid isolation, PCR, Western Blot, cell line engineering, etc.) assays

+ Perform a range of cellular assays including multiparametric flow cytometry

+ Learn and implement cutting edge techniques including but not limited to laser capture microdissection, CRISPR and next generation sequencing under the mentorship and supervision of senior researchers

+ Collaborate with personnel from different research groups (protein engineering, histology, in-vivo pharmacology, discovery)

+ Consistently deliver high-quality, actionable data and actively participate and present at cross-departmental teams and meeting

+ Troubleshoot protocols, develop clear experimental pipelines, maintain detailed records, analyze results, and contribute ideas to research projects

+ Operate and maintain laboratory equipment, and accurately keep and maintain records

Qualifications

Required:

+ B.A./B.S + 5 years’ experience or M.A./M.S. + 3 years’ experience

+ Relevant prior research or industry experience in an oncology drug discovery setting

+ Broad knowledge of cancer biology and independence in critical thinking and scientific achievement

+ Experience with a broad range of cellular and biochemical techniques, including mammalian & tumor cell culture and engineering, signaling and viability assays, immuno-blotting, and FACS.

Preferred:

+ Experience with lentivirus transduction and CRISPR cell line modification and IF/IHC

+ Experience in next generation sequencing library prep (Illumina Platform)

+ Experience with mass spec sample preparation and laser capture microdissection

Working Environment:

+ This position is based in South San Francisco, CA, USA and requires on-site work.

**Salary Range:** $79,800-114,000 (NOTE: Final salary could be more or less, based on experience)

Benefits:

+ Medical, Dental and Vision Insurance

+ Generous Paid Time Off options, including Vacation, Sick time, plus national holidays including Heritage Days, and Summer and Winter Breaks

+ 401(k) match and annual company contribution

+ Company paid life insurance

+ Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

+ Long Term Incentive Plan for eligible positions

+ Referral bonus program

_All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability._

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Category Cancer Biology

Astellas is committed to equality of opportunity in all aspects of employment.

EOE including Disability/Protected Veterans