"Alerted.org

42715BR

Extended Job Title:

HSC Research Associate

Org Level 1:

Texas Tech Unv Hlth Sci Ctr El Paso

Position Description:

Performs specialized work in the planning, conducting and/or supervising of original research at TTUHSC. Responsible for participating in, planning, scheduling and/or supervising research projects and the interpretation of the results for publication. Work is performed under general supervision with evaluation based on accomplishment of assigned objectives and overall effectiveness of project. May supervise research and student assistants. Supports translational and preclinical research projects in oncology drug discovery and therapeutic development. The lab investigates small-molecule and peptide-based modulators targeting oncogenic signaling pathways, tumor microenvironment, hormone resistance, and immune evasion. Plays a key role in the design, execution, and analysis of molecular and in vivo studies evaluating lead compounds across solid tumor models.

Requisition ID:

42715BR

Travel Required:

Up to 25%

Major/Essential Functions:

+ Conduct western blotting, ELISA, and immunoprecipitation assays to study drug–target engagement and pathway inhibition. Perform RNA/protein isolation, qRT-PCR, cloning, mutagenesis, and transient/stable gene manipulation in cancer cell lines. Culture 2D and 3D cancer spheroid models, including lentiviral/siRNA-mediated knockdowns and drug synergy studies

+ Conduct immunofluorescence staining and digital imaging using confocal microscopy to assess subcellular localization and phenotypic markers

+ Perform live-cell imaging and apoptotic/mitotic readouts (Annexin V, TUNEL, Ki-67, H2AX, etc.)

+ Assist in establishing xenograft, syngeneic, and orthotopic tumor models for breast, ovarian, pancreatic, and glioma studies. Conduct drug administration (IP/SC/PO), tumor measurement, survival tracking, necropsy, tissue collection, and histological preparation. Support pharmacokinetic/pharmacodynamic (PK/PD) sample processing and biomarker evaluation

+ Maintain cell line inventory, animal colony genotyping, reagent preparation, and equipment calibration. Guide junior lab members in standard operating procedures and contribute to manuscript and figure preparation. Uphold lab safety, IACUC, and biosafety protocols

+ Remains current with all licensure, certifications and mandatory compliances and trainings required of this position

+ Adhere to all policies, procedures and practices (Regents Rules, TTUS, HSECEP OPs, etc.).

+ Personally demonstrate, display, and act in accordance with TTUHSCEP’s values (Service, Respect, Accountability, Integrity, Advancement and Teamwork). Actively promote and encourage staff across the institution

+ Performs all other duties as assigned

Grant Funded?:

Yes

Minimum Hire Rate:

Compensation is commensurate upon the qualifications of the individual selected

Pay Basis:

Hourly

Work Location:

El Paso

Preferred Qualifications:

+ Master’s degree in biomedical sciences, cancer biology, pharmacology, or molecular biology

+ At least 2 years of laboratory experience, ideally in a translational oncology or therapeutic development setting

+ Proficiency in mammalian cell culture, western blotting, nucleic acid analysis, and fluorescence microscopyWillingness and eligibility to work withmouse tumor models and BSL-2 viral vectors

+ Experience with targeted therapy or drug resistance models (e.g., GR antagonists, Midkine inhibitors, LIFR pathway)

+ Familiarity with survival surgery for PDX or syngeneic tumor implantation and IVIS/bioluminescence imaging

+ Skilled in scientific software (ImageJ/Fiji, GraphPad Prism, Adobe Illustrator, FlowJo)

+ Strong organizational and data management skills with attention to reproducibility and rigor

Campus:

HSC - El Paso

Department:

Molecular and Trans Medicine

Required Attachments:

Cover Letter, Resume / CV, Transcript

Job Type:

Full Time

Pay Statement:

Compensation is commensurate upon the qualifications of the individual selected and budgetary guidelines of the hiring department, as well as, the institutional pay plan. For additional information, please reference the institutional pay plan on the Human Resources webpage.

Job Group:

Research Staff

Shift:

Day

EEO Statement:

All qualified applicants will be considered for employment without regard to sex, race, color, national origin, religion, age, disability, protected veteran status, or genetic information.

Required Qualifications:

+ Master's degree or specialized academic training beyond the Bachelor's level in a particular field of science or engineering equivalent to a Master's degree.

+ Knowledge of modern research practices, the methods, resources, and standards thereof.

In accordance with Texas Executive Order GA-48 and applicable state or federal law, this position may involve access to, work on, or conduct research involving critical infrastructure. It will require background checks, including, but not limited to, criminal history and other security-related screenings. Employment is contingent upon the successful completion of these checks.

Does this position work in a research laboratory?:

Yes

Are select agents used in this laboratory?:

Yes

Jeanne Clery Act:

The Jeanne Clery Disclosure of Campus Security Policy and Campus Crime Statistics Act is a federal statute requiring colleges and universities participating in federal financial aid programs to maintain and disclose campus crime statistics and security information. By October 1 of each year, institutions must publish and distribute their Annual Campus Security Policy & Crime Statistics Report (ASR) to current and prospective students and employees. You can locate this report through our website at: https://www.ttuhsc.edu/emergency/clery-report.aspx