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42740BR

Extended Job Title:

HSC Post Doctoral Rsch Assoc

Org Level 1:

Texas Tech Unv Hlth Sci Ctr El Paso

Position Description:

Performs specialized Post Doctoral work in the planning, conducting and/or supervision of original research at TTUHSC. Responsible for participating in a research project associated with Ph.D studies and the interpretation of the results of publication. Work is performed under supervision of graduate faculty members with evaluation based on accomplishment of assigned objectives and overall effectiveness of project. May supervise research and student assistants. The Postdoctoral Fellow will lead mechanistic and translational research projects in preclinical oncology drug development, with an emphasis on signaling pathway modulation, ligand–receptor biology, and therapeutic resistance. The candidate will develop and characterize novel small molecules and peptide-based therapeutics using cellular, molecular, and in vivo models across solid tumors. Projects are supported by NIH, CPRIT, and SBIR mechanisms, with opportunities for high-impact publications, patentable discoveries, and biotech-industry collaborations.

Requisition ID:

42740BR

Travel Required:

Up to 25%

Major/Essential Functions:

+ Investigate drug–target interactions using techniques such as immunoprecipitation, western blotting, phospho-proteomics, TR-FRET, MST, and co-immunostaining. Elucidate oncogenic and immunomodulatory pathways including Midkine, LIF/LIFR/STAT3, GR signaling, and IFN- activation

+ Perform CRISPR knockouts, overexpression/siRNA modulation, and reporter assays in cancer cell lines. Assess cytotoxicity, synergy (Bliss/HSA models), and rescue experiments to identify therapeutic index and combination strategies.

+ Design and execute syngeneic, xenograft, orthotopic, PDX and women’s health research mouse models of preterm birth, uterine fibroids and endometriosis.

+ Conduct pharmacokinetic (PK), pharmacodynamic (PD), and efficacy evaluations using standard and imaging-based (e.g., IVIS) readouts.

+ Analyze human and mouse tissue samples for RNA/protein expression and immune infiltration using qPCR, IHC/IF, and multiplex imaging. Integrate preclinical findings with transcriptomic datasets and public repositories for signature development.

+ Manuscript and Grant Preparation: Prepare data for publication in peer-reviewed journals and present at national/international conferences. Contribute to writing research grants, patents, and regulatory documentation as needed.

+ Remains current with all licensure, certifications and mandatory compliances and trainings required of this position.

+ Adhere to all policies, procedures and practices (Regents Rules, TTUS, HSECEP OPs, etc.).

+ Personally demonstrate, display, and act in accordance with TTUHSCEP’s values (Service, Respect, Accountability, Integrity, Advancement and Teamwork). Actively promote and encourage staff across the institution.

+ Performs all other duties as assigned.

Grant Funded?:

Yes

Minimum Hire Rate:

Compensation is commensurate upon the qualifications of the individual selected

Pay Basis:

Monthly

Work Location:

El Paso

Preferred Qualifications:

+ Ph.D. in Cancer Biology, Molecular Pharmacology, Biomedical Sciences, or related field

+ Demonstrated expertise in mammalian cell culture, western blotting, and in vivo mouse models

+ Strong publication record n peer-reviewed journals (at least one first-author paper preferred)

+ Excellent oral and written communication skills

+ Experience with receptor-ligand biology (e.g., Midkine, LIF/LIFR, other novel targets)

+ Familiarity with target engagement assays (TR-FRET, MST, CETSA) or transcriptomic analysis (RNA-seq, qPCR)

+ Skilled in Adobe Illustrator, GraphPad Prism, ImageJ/Fiji, and relevant bioinformatics tools

+ Background in women’s health models, immuno-oncology, or endocrine resistance models is a plus

Campus:

HSC - El Paso

Department:

Molecular and Trans Medicine

Required Attachments:

Cover Letter, Resume / CV, Transcript

Job Type:

Full Time

Pay Statement:

Compensation is commensurate upon the qualifications of the individual selected and budgetary guidelines of the hiring department, as well as, the institutional pay plan. For additional information, please reference the institutional pay plan on the Human Resources webpage.

Job Group:

Research Staff

Shift:

Day

EEO Statement:

All qualified applicants will be considered for employment without regard to sex, race, color, national origin, religion, age, disability, protected veteran status, or genetic information.

Required Qualifications:

+ PhD in area of project specialization

+ Knowledge of modern research practices, the methods, resources, and standards thereof

+ Ability to organize work effectively, conceptualize and prioritize objectives and exercise independent judgment based on an understanding of organizational policies and activities

+ Ability to integrate resources, policies, and information for the determination of procedures, solutions and other outcomes

+ Ability to establish and maintain effective work relationships with other employees and the public

+ Ability to plan and allocate the workload of employees, providing direct training and supervision as needed

In accordance with Texas Executive Order GA-48 and applicable state or federal law, this position may involve access to, work on, or conduct research involving critical infrastructure. It will require background checks, including, but not limited to, criminal history and other security-related screenings. Employment is contingent upon the successful completion of these checks.

Does this position work in a research laboratory?:

Yes

Are select agents used in this laboratory?:

Yes

Jeanne Clery Act:

The Jeanne Clery Disclosure of Campus Security Policy and Campus Crime Statistics Act is a federal statute requiring colleges and universities participating in federal financial aid programs to maintain and disclose campus crime statistics and security information. By October 1 of each year, institutions must publish and distribute their Annual Campus Security Policy & Crime Statistics Report (ASR) to current and prospective students and employees. You can locate this report through our website at: https://www.ttuhsc.edu/emergency/clery-report.aspx