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Overview

WuXi AppTec Biology, offers biology-focused preclinical drug discovery services to biotech and pharmaceuticals. We offer our clients comprehensive service platforms around target validation, plate-based pharmacology, hit identification and lead discovery, in vivo pharmacology, as well as other research and development services.

We are seeking a highly motivated and versatile scientist to advance our neuroscience platforms and broader discovery programs aimed at developing therapies for neurodegenerative, neuroinflammatory, and other complex diseases. The successful candidate will design, develop, and execute sophisticated in vitro assays using human iPSC-derived neurons, primary neuronal cells, co-culture systems, and additional cellular models. In addition to neuroscience, this role will also support cross-functional projects involving general cell biology, immunology, and translational assays. Strong technical depth, assay development expertise, and the ability to collaborate effectively in a multidisciplinary environment are essential.

Responsibilities

• Design, optimize, and execute in vitro neuroscience assays using iPSC-derived neurons, astrocytes, primary neuronal cells, and other CNS-relevant cell types.

• Develop and characterize co-culture models (e.g., neuron–microglia, neuron-astrocyte, multi-lineage systems) to study disease mechanisms.

• Support discovery programs with key functional readouts, including neurite outgrowth, neuronal survival, synaptic activity, and high-content imaging.

• Perform molecular and cellular analyses such as qPCR, flow cytometry, ELISA, imaging-based assays, and protein/RNA quantification.

• Contribute to non-neuroscience projects, including general cell biology assays, immune cell functional assays, iPSC-derived non-CNS lineages, and other translational models as needed.

• Independently manage multiple projects, ensuring rigorous experimental design, high-quality execution, and reproducible data generation.

• Prepare clear and well-structured data summaries, technical reports, and presentations for internal teams and external partners.

Qualifications

• Ph.D. in Neuroscience, Stem Cell Biology, Cell Biology, or a related field with 4-6 years of postdoctoral or industry research experience.

• Strong knowledge of neurodegenerative and neuroinflammatory diseases, including relevant cellular and molecular mechanisms.

• Extensive hands-on expertise with iPSC-derived neuronal culture systems and advanced cellular neuroscience models.

• Demonstrated experience developing and applying co-culture assays and functional neuronal readouts (e.g., neurite outgrowth, synaptic activity, survival assays).

• Experience with organoid or 3D culture systems is a strong plus.

• Broader expertise in general cell biology, immunology, or iPSC-derived non-CNS cell types is highly valued.

• Proven ability to manage multiple projects effectively, with strong organizational and multitasking skills.

• Excellent written, oral, and interpersonal communication skills.

Physical Requirements:

• Must be able to work in an office environment with minimal noise conditions

• Must be able to work in a lab setting with exposure to Animals/biohazards /Chemicals (List

• specific Chemicals)

• Must not have animal allergies to applicable species in this facility.

• Must be able to work in environment with variable noise levels.

• Ability to stand/Sit/walk for long periods of time.

• Ability to Lift 10 lbs routinely.

• Ability to push/pull 10 lbs. routinely/often/occasionally

• Clarity of vision.

• Ability to identify and distinguish colors.

• Must be able to perform activities with repetitive motions.

• Ability to climb ladders/stairs/scaffolding.

• Ability to work in variable temperatures high to freezing.

• Inside/outside working conditions.

Anticipated base pay range: $80,322 to $104,000

An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability

This job description does not state or imply that the above are the only duties and responsibilities assigned to this position. Employees holding this position will be required to perform any other job-related duties as requested by Management.

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An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disabilityAn Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability (https://careers-wuxiapptec.icims.com/connect?back=intro&findajob=1&in\_iframe=1&hashed=-435740542)

**Job Locations** _US-CA-San Diego_

**Job ID** _2025-13872_