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Scientist II, BioConjugation, Antibody Drug Conjugate

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com .

Purpose:

Our research division is looking for a Scientist to work on bioconjugation for Antibody-Drug Conjugates (ADCs), primarily focusing on bioconjugation and purification of ADC to drive projects in SSF. In this position, you will work closely with Antibody Engineering group to advance our project.

Essential Job Responsibilities:

+ Perform conjugation and purification to prepare ADCs to support research activities

+ Design, optimize and develop CMC friendly conjugation process

+ Lead the creation of optimal ADC clinical candidates by appropriate conjugation methods.

+ Manage CROs to perform above activities

+ Actively participate in ADC projects, contributing to team decision-making through the creation of ADCs and the data you generate.

+ Serve as an ADC Subject Matter Expert (SME), offering appropriate advice and solutions.

+ Contribute to patents, publications, and technical reports.

Qualifications Required:

+ PhD with 2+ years relevant laboratory experience in biologics research

+ Extensive hands-on experience with a wide range of conjugation chemistry, including but not limited to lysine, cysteine, and enzymatic mediated conjugation methods

+ Experience in analytical methods for protein characterization, ideally antibody related modalities

+ Desire and ability to work in cross-functional, flexible and team-oriented environment

+ CRO management experience

+ Well-balanced communication skills (active & passive) in own language and in English

Preferred:

+ Experience in antibody-related modality development especially in antibody-drug conjugates (ADCs)

+ Experience supporting ADC development from discovery to early CMC development

+ Experience in oncology research.

+ Experience in patent application

+ Experience in collaborations with external research groups

Working Environment:

+ This position is based in SSF and will require on-site work.

**Salary Range:** $103,600-$162,800 (Final compensation will be determined based on a variety of factors, including but not limited to skills, experience, and organizational equity considerations).

Benefits:

+ Medical, Dental and Vision Insurance

+ Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down

+ 401(k) match and annual company contribution

+ Company paid life insurance

+ Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

+ Long Term Incentive Plan for eligible positions

+ Company-paid fleet vehicle for eligible positions

+ Referral bonus program

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Category Biologics Engineering

Astellas is committed to equality of opportunity in all aspects of employment.

EOE including Disability/Protected Veterans