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ADC Biologist, BioConjugation, Antibody Drug Conjugate

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com .

Purpose:

Our research division is looking for a Scientist to lead bioconjugation for Antibody-Drug Conjugates (ADCs), primarily focusing on bioconjugation and ADC characteristics to drive projects in SSF. In this position, you will guide the establishment of efficient conjugation, spanning from the development of novel ADC technologies to the creation of clinical candidates. You'll work closely with relevant departments both domestically and internationally to advance our pipeline.

Essential Job Responsibilities:

+ Actively participate in cross functional ADC projects to guide ADC discovery and development

+ Design and execute in vitro and in vivo assays and studies to evaluate ADC mechanism of action, potency, internalization, and payload release

+ Support the development and implementation of new methodologies to improve ADC screening and characterization.

+ Analyze, interpret, and present complex datasets to project teams and senior leadership.

+ Serve as an ADC Subject Matter Expert (SME), offering appropriate advice and solutions.

+ Develop novel ADC-related technologies and explore external technological advancements

+ Contribute to patents, publications, and technical reports

Qualifications Required:

+ PhD with typically 5+ years’ experience in ADC discovery and development

+ Deep understanding of ADC biology and MOA

+ Desire and ability to work in cross-functional, flexible and team-oriented environment

+ CRO management experience

+ Well-balanced communication skills (active & passive) in own language and in English

Preferred:

+ Experience in antibody-related modalities development especially in antibody-drug conjugates (ADCs)

+ Experience working with cross functional teams

+ Experience in different payload classes and understanding of their MOA

+ Experience in oncology research.

+ Experience in patent application

+ Experience in collaborations with external research groups

Working Environment:

+ This position is based in SSF and will require on-site work.

**Salary Range:** $119,000-$187,000 (Final compensation will be determined based on a variety of factors, including but not limited to skills, experience, and organizational equity considerations).

Benefits:

+ Medical, Dental and Vision Insurance

+ Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down

+ 401(k) match and annual company contribution

+ Company paid life insurance

+ Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

+ Long Term Incentive Plan for eligible positions

+ Company-paid fleet vehicle for eligible positions

+ Referral bonus program

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Category Biologics Engineering

Astellas is committed to equality of opportunity in all aspects of employment.

EOE including Disability/Protected Veterans