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A fully supported Scientist IV position is available in the cross-disciplinary Coler Lab (Coler Lab - Center for Global Infectious Disease Research (https://www.seattlechildrens.org/research/centers-programs/global-infectious-disease-research/research-areas-and-labs/coler-lab/) ) to characterize immune response of novel vaccines and immune pathology associated with tuberculosis and co-morbidities, as well as how the microbiome and associated ecological and evolutionary factors affect our immune response. Previous experience in cellular immunology is required. Additionally, we seek candidates with experience in bioinformatics and/or computational approaches to analyzing vaccine induced immune responses and the microbiome. This Scientist will ask fundamental biological questions about host-pathogen interactions in the lung mucosa and will study of correlates of protection and risk.

Interested applicants should provide a cover letter detailing their scientific achievements, goals, and a description of their interest, in addition to a curriculum vitae that indicates their education, experience, and qualifications.

Job Description

Responsible to plan, design and execute research development activities in support of funded research projects. Design approaches or hypotheses to be tested and methodology to be used; design specific phases of research projects.

Perform experimental procedures and make detailed observations; analyze and interpret data. Application of computational methods to complex biological systems; Development of computational infrastructure for processing and analysis of next generation sequencing datasets, including isolate and metagenomic studies; Extraction of nucleic acid from various biological sources and preparation of next generation sequencing libraries; Normalization, integration, and analysis of datasets of multiple modalities.

Works closely with principal investigator on the development of technical proposals, presentations manuscripts and grants. Plans and conducts work requiring independent judgment in the evaluation, selection, and substantial adaptation/modification of standard techniques, procedures and criteria. Maintain accurate documentation; ensure protocols are available to research team members. Uses a wide application of complex principles, theories and concepts in specific scientific discipline. Able to guide technical staff and provide training in protocols and laboratory techniques in BSL2 and BSL3 settings. Writes original reports incorporating data analysis and able to meet specifically agreed upon deadlines. Contribute proportional intellectual content to team efforts.

Required Education and Experience

PhD or M.D. in Molecular or Cellular Biology, Biochemistry, or other closely related field.

Minimum of four (4) years experience in required field of specialization.

Prior experience with laboratory management or other relevant research field.

Required Credentials

N/A.

Preferred

- Experience and technical skills in next-generation sequencing, multi-omics approaches, deep understanding of immunology and/or human biomarker research

- Demonstrated coding skills in one or more programming languages (i.e., Python, R, shell scripting, or similar)

- Proficiency in MS Office, scientific data/graphics programs, bioinformatics, and biostatistics

- A strong track record of publication

- Experience working under Biosafety Level 2 or 3 (BL2/BL3) conditions

- Willingness and ability to work under BL3 conditions with appropriate training

- Experience working with small animal models of infectious diseases

- Excellent oral and written communication skills in English

- Must be self-motivated, highly organized and be able to work on teams

Compensation Range

$107,431.00 - $161,147.00 per year

Salary Information

This compensation range was calculated based on full-time employment (2080 hours worked per calendar year). Offers are determined by multiple factors including equity, skills, experience, and expertise, and may vary within the range provided.

Disclaimer for Out of State Applicants

This compensation range is specific to Seattle, positions located outside of Seattle may be compensated differently depending on various factors **.**

Benefits Information

Seattle Children’s offers a generous benefit package, including medical, dental, and vision plans, 403(b), life insurance, paid time off, tuition reimbursement, and more. Additional details on our benefits can be found on our website www.seattlechildrens.org/careers/benefits .

About Us

Hope. Care. Cure. These three simple words capture what we do at Seattle Children’s – to help every child live the healthiest and most fulfilling life possible. Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #HOPECARECURE

As one of the nation's top five pediatric research centers, Seattle Children's Research Institute is dedicated to providing hope, care, and cures to help every child live the healthiest and most fulfilling life possible.

Our investigators are involved in hundreds of projects that cover every phase of research, from studying how diseases work to improving investigational therapies. They have pioneered groundbreaking cystic fibrosis treatments and cutting-edge cancer therapies that help a child's immune system defeat cancer, and made other major contributions to pediatric medicine.

Researchers work in close collaboration with one another, their colleagues at partner institutions including the University of Washington and Fred Hutch and our healthcare providers at Seattle Children's Hospital, one of U.S. News & World Report’s top children's hospitals. This collaboration is one of our key strengths, allowing our faculty to draw on a variety of disciplines and techniques as they pursue solutions to some of medicine's most complex problems.

We are committed to not only treating disease but to eliminating it. Help us achieve our vision of being a worldwide leader in pediatric research aimed to improve the health and well-being of children. If you are interested in a challenging career aimed at groundbreaking research, Seattle Children's Research Institute is the place for you.

Our Commitment

Seattle Children’s welcomes people of all experiences, backgrounds, and thoughts as this is what drives our spirit of inquiry and allows us to better connect with our patients and families. Our organization recruits, employs, trains, compensates, and promotes based on merit without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.

The people who work at Seattle Children’s are members of a community that seeks to respect and celebrate all the qualities that make each of us unique. Each of us is empowered to be ourselves.

Seattle Children’s is proud to be an Equal Opportunity Workplace and Affirmative Action Employer.