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Job Description

Department: Division of Gastroenterology

Physical work location: 1425 Madison Ave, New York, NY 10029

Name PI or Supervisor: Saurabh Mehandru

Web link to Lab: https://www.mountsinai.org/locations/ibd-center

Administrative Contact: Erica Krasny

Qualifications

Expected Outcomes :

Ultimately, the expectations we may have from this project are to **support the development of tailored therapeutic strategie** s that best suit immunocompromised individuals, based on a clear understanding of the immune pathways dysregulated. This work may also **unravel new knowledge on how B cells, T cells and myeloid cells control gut homeostasis.**

PhD or MD

Responsibilities

The main objective of my PhD project will be to identify dysregulated immune networks triggering and sustaining inflammation in CVID patients with GI tract disorders. My work will focus on the study of human gastrointestinal biopsies. I will use a **combination of single cell RNA sequencing (scRNA-seq), high dimensional flow cytometry, and whole slide, high-resolution multiplex imagery approaches** , to identify the functional alterations of immune cells within the CVID inflamed gut and/or stomach mucosa.

The project will be structured around three specific aims (described in the following section “Goals/Outcomes of the Research Project”) : **1) Investigating the** **cellular and molecular organizations of gut inflammatory lesions in CVID** ; **2) Addressing the** **role of B cells and autoantibodies** in the pathogenesis of CVID gut inflammatory lesions ; **3)** **Dissecting altered molecular trajectory of myeloid cells** in CVID.

This PhD project will be co-supervised by Prof. Saurabh Mehandru (MD-PhD, Icahn School of Medicine at Mount Sinai, New-York, USA) and Prof. Jérôme Martin (PhD, Nantes University, France). It will be part of an international, pre-existing **collaboration between Nantes University and the Icahn School of Medicine at Mount Sinai** , contributing to a translational research effort ultimately aimed at benefiting patients.

About Us

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.

About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.

Compensation Statement

Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.