• Senior Research Scientist

    Actalent (Wilmington, DE)


    Job Description:

    We are seeking a highly skilled and motivated Scientist to

    support in‑vitro studies for cancer drug discovery programs. This contract role

    focuses on developing and applying preclinical model systems to identify and

    validate novel therapeutic targets. The ideal candidate brings strong molecular

    and cellular biology expertise, works independently, and demonstrates a solid

    understanding of cancer biology. Experience with oncogenic signaling pathways

     

    and targeted therapies is highly advantageous. The Scientist will partner

     

    closely with their supervisor to design and execute research plans that address

     

    key mechanistic questions around compounds and targets under evaluation.

    Key Responsibilities

    + Design, execute, and interpret experiments using chemical and genetic modalities with a high level of scientific independence.

    + Develop and deploy disease‑relevant preclinical models to interrogate target biology and explore complex mechanistic hypotheses.

    + Contribute to small‑ and large‑molecule screening efforts across exploratory research and lead optimization programs, ensuring high‑quality, translationally relevant data.

    + Collaborate effectively with cross‑functional teams within drug discovery to advance shared program goals.

    + Adapt to evolving project needs by acquiring new technical skills and competencies as required.

    + Communicate complex scientific findings clearly to internal and external audiences through written reports and presentations.

    Required Qualifications

    + Bachelor’s degree in Molecular Biology, Stem Cell Biology, or a related field with 5+ years of relevant industry experience; OR Master’s degree with 2+ years of experience; OR Ph.D. with 3+ years of postdoctoral or equivalent research experience.

    + Demonstrated experience developing, optimizing, and executing functional cellular assays (e.g., proliferation, differentiation, apoptosis).

    + Strong theoretical and hands‑on expertise working with primary stem cells; experience in hematopoietic stem cell biology or myeloid malignancies (MPN, MDS, AML) is strongly preferred.

    + Proficiency in core molecular and cellular biology techniques, including:

    + ELISA

    + MSD‑based assays

    + Western blotting

    + Multicolor flow cytometry

    + CRISPR/Cas9 gene‑editing platforms

    + Experience with CRISPR‑based screening approaches is a plus.

    + Familiarity with 3D tissue or organoid models to recapitulate disease biology in physiologically relevant systems.

     

    Job Type & Location

     

    This is a Contract position based out of Wilmington, DE.

    Pay and Benefits

    The pay range for this position is $38.00 - $43.27/hr.

     

    Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following: • Medical, dental & vision • Critical Illness, Accident, and Hospital • 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available • Life Insurance (Voluntary Life & AD&D for the employee and dependents) • Short and long-term disability • Health Spending Account (HSA) • Transportation benefits • Employee Assistance Program • Time Off/Leave (PTO, Vacation or Sick Leave)

     

    Workplace Type

     

    This is a fully onsite position in Wilmington,DE.

     

    Application Deadline

     

    This position is anticipated to close on Jan 27, 2026.

    About Actalent

    Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

     

    The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

     

    If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing due to a disability, please email [email protected] (%[email protected]) for other accommodation options.