- Amgen (South San Francisco, CA)
- …us and transform the lives of patients while transforming your career. **Senior Scientist - PKDM (NAMs-Based Translational ADME Sciences)** **What you will do** ... improve translational prediction of drug disposition, target engagement, and pharmacodynamic response. You will play a pivotal role in establishing NAMs-based… more
- AbbVie (South San Francisco, CA)
- …will establish innovative translational modeling approaches, such as mechanistic PK / PD or systems modeling, across disease and therapeutic areas, as ... ADME Sciences (QTAS) group is searching for a Senior Scientist to provide mechanistic and translational modeling...and other stakeholders, to develop and execute QTAS and PK / PD strategies necessary to facilitate the advancement… more
- Amgen (South San Francisco, CA)
- … Translational and Clinical Pharmacology approaches - such as Pharmacokinetic / Pharmacodynamic ( PK / PD ) modeling, Mechanistic-Physiologically Based ... Pharmacokinetic (M-PBPK) modeling, Mechanistic-PBPK- Pharmacodynamic (M-PBPK- PD ) modeling, Quantitative Systems Pharmacology (QSP) modeling - integrated with… more
- AbbVie (Irvine, CA)
- …to contribute to optimizing translational sciences strategies. + Analysis of PK / PD data, both clinical and nonclinical, through the use of sophisticated ... modeling and simulation expert with matrix project teams. Specific responsibilities include: + Apply PK and PK / PD modeling/simulation to guide the design and… more
- Gilead Sciences, Inc. (Foster City, CA)
- …**Biologics DMPK Senior Scientist ** position is to serve as an expert in pharmacokinetic ( PK ) and PK / PD modeling of biologics, providing strategic ... strategies with scientists, collaborators, and management. + Design, implement, andvalidatecomplex PK / PD and mechanistic modelsto address translational … more
- Merck (South San Francisco, CA)
- …workflow. + Design and execute in vitro and in vivo mechanistic and translational studies to evaluate the pharmacokinetic and metabolic properties of therapeutic ... and other modalities, to influence drug design, lead selection, and drive PK / PD translations. Be accountable for providing timely and high-quality PDMB… more
- Merck (South San Francisco, CA)
- …inhaled drug delivery systems and formulation development. + Proficiency in pharmacology, PK / PD modeling, and translational science for respiratory ... **Job Description** We are seeking an experienced scientist to join our team and drive innovation...Design and execute strategies for target identification, validation, and translational approaches in respiratory disease areas (eg, COPD, asthma,… more
- Bristol Myers Squibb (San Diego, CA)
- …oncology and immune-oncology + Independently design and execute in vivo efficacy and PK / PD experiments to identify drug candidates + Analyze and interpret data ... endpoints to assess efficacy. Collaboration with DMPK, Exploratory Toxicology, and Translational Development is central to our work, and we contribute preclinical… more
- Amgen (South San Francisco, CA)
- …During this program , you will apply principles of pharmacokinetics/pharmacodynamics ( PK / PD ), translational pharmacology, and mechanistic modeling to ... chemical or biomedical engineering, or a related discipline. + Demonstrated experience with PK / PD , QSP, or PBPK modeling or other computational modeling and data… more
- University of Southern California (Los Angeles, CA)
- …+ Build and analyze dynamical system models (multiscale, QSP, PBPK, PK - PD ). + Apply numerical methods, optimization, and parameter estimation ... Responsibilities: * Build and analyze dynamical system models (multiscale, QSP, PBPK, PK - PD ). * Apply numerical methods, optimization, and parameter estimation… more